Regulation of whole-body metabolism and adiposity is a complex interplay between calorie intake, environmental pressures and energy expenditure.
Caloric sensing involves a variety of biochemical messengers and hormones such as incretins, adipokines, hepatokines, and myokines that facilitate inter-organ crosstalk to modulate behavior and the regulation of calorie storage and utilization.
Two critical gut peptides that regulate many physiological processes are the incretin hormones GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1).
With Carmot’s investigational candidates, CT-388 and CT-868, we combine the physiological effects of GLP-1 and GIP into single molecular entities that, we believe, have the advantages of harnessing the multiple biological effects of the two hormones into one.
Potent systemic multifactorial effects.
CT-868 is an acylated unimolecular biased dual GLP-1 and GIP receptor modulator administered once a day.
CT-388 is longer acting (once weekly) molecule with the same signaling attributes as CT-868.
FAT, MUSCLE, LIVER