Understanding Energy Homeostasis

Carmot is part of a paradigm shift in the treatment of metabolic diseases, including obesity and diabetes, by developing a portfolio of therapeutics that target the root causes of disease.

Regulation of whole-body metabolism and adiposity is a complex interplay between calorie intake, environmental pressures and energy expenditure.

Caloric sensing involves a variety of biochemical messengers and hormones such as incretins, adipokines, hepatokines, and myokines that facilitate inter-organ crosstalk to modulate behavior and the regulation of calorie storage and utilization.

Two critical gut peptides that regulate many physiological processes are the incretin hormones GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1).

With Carmot’s investigational candidates, CT-388 and CT-868, we combine the physiological effects of GLP-1 and GIP into single molecular entities that, we believe, have the advantages of harnessing the multiple biological effects of the two hormones into one.

Actions of CT-868 and CT-388

Potent systemic multifactorial effects.

CT-868 is an acylated unimolecular biased dual GLP-1 and GIP receptor modulator administered once a day.

CT-388 is longer acting (once weekly) molecule with the same signaling attributes as CT-868.

GLP-1R GIPR
CT-868 / CT-388
Brain
  • appetite
  • satiety
  • body weight
  • neuroprotection
  • appetite
  • body weight
Stomach
  • gastric emptying
Pancreas
  • insulin
  • glucagon
  • blood glucose
  • β-cell protection
  • insulin
  • β-cell protection
Bone
  • bone resorption
  • bone formation
Muscle

MUSCLE, LIVER

  • glucose uptake
  • glucose production
  • ectopic fat accumulation
  • insulin sensitivity
Fat

FAT, MUSCLE, LIVER

  • glucose uptake
  • glucose production
  • ectopic fat accumulation
  • insulin sensitivity
  • lipid storage
  • blood flow
  • inflammation
  • insulin sensitivity
Kidney
  • oxidative stress and inflammation
  • tubulointerstitial fibrosis
  • renoprotection
Liver
Heart
  • cardiac function
  • cardio protection
  • cardiac and vascular function
Brain
  • appetite
  • satiety
  • body weight
  • neuroprotection
  • appetite
  • body weight
Stomach
  • gastric emptying
Pancreas
  • insulin
  • glucagon
  • blood glucose
  • β-cell protection
  • insulin
  • β-cell protection
Bone
  • bone resorption
  • bone formation
Muscle, Liver
  • glucose uptake
  • glucose production
  • ectopic fat accumulation
  • insulin sensitivity
Fat
  • glucose uptake
  • glucose production
  • ectopic fat accumulation
  • insulin sensitivity
  • lipid storage
  • blood flow
  • inflammation
  • insulin sensitivity
Kidney
  • oxidative stress and inflammation
  • tubulointerstitial fibrosis
  • renoprotection
Heart
  • cardiac function
  • cardio protection
  • cardiac and vascular function