Understanding Energy Homeostasis

Carmot is part of a paradigm shift in the treatment of metabolic diseases, including obesity and diabetes, by developing a portfolio of product candidates that target the root causes of disease.

Regulation of whole-body metabolism and adiposity is a complex interplay between calorie intake, environmental pressures and energy expenditure.

Caloric sensing involves a variety of biochemical messengers and hormones such as incretins, adipokines, hepatokines, and myokines that facilitate inter-organ crosstalk to modulate behavior and the regulation of calorie storage and utilization.

Two critical gut peptides that regulate many physiological processes are the incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide).

Our clinical pipeline targets GLP-1 and GIP, both of which play significant roles in energy homeostasis.