Our Pipeline

Advancing new potential treatments for millions of people living with metabolic diseases including obesity and diabetes.

Indications
Program
Target
Phase
Discovery
Preclinical
Phase 1
Phase 2
Phase 3
Commercial
Rights
Metabolic
Obesity
Type 2 Diabetes
CT-388
peptide
Once-weekly GLP-1/GIP dual receptor modulator
Phase 2
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Rights: Carmot
CT-388
peptide

CT-388 is an investigational once-weekly, injectable, dual GLP-1/GIP receptor modulator being studied in a multi-part, multi-cohort Phase 1/2 trial to assess its safety, tolerability, pharmacokinetics and pharmacodynamic effects vs. placebo in overweight and obese heathy volunteers as well as in a cohort of overweight and obese participants with type 2 diabetes. Further details about the trial can be found at https://clinicaltrials.gov/ct2/show/NCT04838405.

Type 1 Diabetes
CT-868
peptide
Once-daily GLP-1/GIP dual receptor modulator
Phase 2
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Rights: Carmot
CT-868
peptide

CT-868 is an investigational once-daily, injectable dual GLP-1/GIP receptor modulator being studied in two trials:

  • CT-868-002: A Phase 2 global multi-center double blind, randomized placebo-controlled dose-ranging trial assessing efficacy and safety over 26 weeks in overweight and obese participants with type 2 diabetes.
  • CT-868-005: A randomized, double-blind, placebo and comparator-controlled crossover study to assess the effects of CT-868 treatment on glucose homeostasis in participants with type 1 diabetes. Further details about the trial can be found at https://clinicaltrials.gov/ct2/show/NCT05794581.
Obesity
Type 2 Diabetes
CT-996
small molecule
GLP-1 receptor agonist
Phase 1
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Rights: Carmot
CT-996
small molecule

CT-996 is an investigational once-daily, oral, small molecule GLP-1 receptor agonist) being studied in a Phase 1 clinical trial to assess its safety, tolerability, pharmacokinetic and pharmacodynamic effects in overweight/obese adults with and without type 2 diabetes.

Orphan
Indications
and combination
products
peptide
PYY
Preclinical
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Rights: Carmot
Type 2 Diabetes
Obesity
End-organ complications
small molecules
undisclosed
Discovery
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Rights: Carmot

CT-388, CT-868 and CT-996 are investigational clinical candidates.